A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation…

After experiencing financial issues, DNA testing company Veritas Genetics has announced the suspension of its U.S. operations in an unexpected announcement on December 4th 2019. The company is perhaps best known for being co-founded by renowned Harvard University geneticist George Church and has been working towards reducing the costs of genome sequencing so that it…

A team of researchers, including Dr. David Sinclair, has recently made a new study available as a preprint prior to peer review and publication in the journal Cell. DNA damage and the double-strand break Two of the primary hallmarks of aging are genomic instability, which consists of damage to our DNA, and epigenetic alterations, which…

The July journal club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater extent…

According to a study conducted by Hollings Cancer Center scientists at the Medical University of South Carolina, DNA replication in murine cells is possible even in the absence of origin recognition complex 1 (ORC1), a protein encoded by the homonymous gene that was previously thought to be indispensable [1]. Study abstract The largest subunit of…

Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging. DNA damage as a driver of aging Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage…

On May 1, around 200 scientists from the Genome Project-write (GP-write) met in Boston and announced the first target of their project: the creation of cells that cannot be infected by viruses. What is the Genome Project-write? GP-write includes sub-projects like the Human Genome Project-write (HGP-write), which was formally announced on June 2, 2016, and…

Researchers have demonstrated how alcohol damages mouse stem cell DNA in a new study, helping to explain why drinking can increase cancer risk[1]. The study was published in the journal Nature on January 3. There have been multiple cell culture studies looking at how alcohol promotes cancer, but this study used mice to show how…

The Hallmarks of Aging, published in 2013, is highly regarded in academia and is one of the most cited papers in biology, with an average of being cited once every two days. The paper divides aging into nine distinct categories (“hallmarks”) of damage to explain how aging processes work and how they cause age-related diseases…

Many of you will likely already know who Professor George Church is, and that he is an important and senior member of the research community engaged in treating the aging processes to prevent or reverse age-related diseases, not to mention all kinds of other applications for genetic engineering. For those who are not familiar with…

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