Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging. DNA damage as a driver of aging Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage…

On May 1, around 200 scientists from the Genome Project-write (GP-write) met in Boston and announced the first target of their project: the creation of cells that cannot be infected by viruses. What is the Genome Project-write? GP-write includes sub-projects like the Human Genome Project-write (HGP-write), which was formally announced on June 2, 2016, and…

Researchers have demonstrated how alcohol damages mouse stem cell DNA in a new study, helping to explain why drinking can increase cancer risk[1]. The study was published in the journal Nature on January 3. There have been multiple cell culture studies looking at how alcohol promotes cancer, but this study used mice to show how…

We are doing a series of articles that discuss the Hallmarks of Aging. Published in 2013, this paper is highly regarded in academia and is one of the most cited papers in biology, with an average of being cited once every two days. The paper divides aging into distinct categories (“hallmarks”) of damage to explain…

Many of you will likely already know who Professor George Church is, and that he is an important and senior member of the research community engaged in treating the aging processes to prevent or reverse age-related diseases, not to mention all kinds of other applications for genetic engineering. For those who are not familiar with…

CRISPR (otherwise known as “Clustered Regularly Interspaced Short Palindromic Repeat”) is a gene editing system, but it is not a human invention. It was originally part of the antiviral ‘immune system’ of a particular form of bacteria. Unlike our immune system, which destroys cells infected with viruses, CRISPR seeks to destroy the actual virus itself,…

Researchers at the Scripps Research Institute Florida campus have refined the already state-of-the-art gene-editing system CRISPR. The new improvements boost the ability of CRISPR to target, cut, and paste genes in human and animal cells and helps to address the concerns of off-target gene mutations raised in a recent study[1]. What is CRISPR? CRISPR is short…

DNA is a critical part of cells, the instruction manual for building them. Whilst DNA is well protected within the cell nucleus, damage does occur, therefore DNA repair is absolutely essential for cell function, cell survival, and the prevention of cancer. The good news is, cells are able to repair damaged DNA, but the bad…

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