The role of epigenetics, which determine how your genes are expressed, is being increasingly implicated in aging, as is the potential of therapies that revert epigenetics back to those of a younger person. What are epigenetic alterations? The DNA in each of our cells is identical, with only some small variations, so why do our…

A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan. The epigenetic clock As we age, our DNA experiences chemical changes called DNA methylation (DNAm); these changes are used as a way to measure age and are…

Today, we chronicle the progress of OSKM and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing the hallmark of epigenetic alterations and other hallmarks as well. The birth of cellular reprogramming In 2006, a study by Drs. Takahashi and Yamanaka showed that it…

At the Fourth Eurosymposium on Healthy Ageing, which was held in Brussels last November, Elena and I met Dr. Kris Verburgh, a medical doctor who is especially interested in biogerontology and the potential of this field of study to turn medicine on its head. Dr. Verburgh is only about 33 years old and has already…

Today, we conclude our two-part interview with Dr. Michael Fossel, you can find part one here. Changing tack a bit here, you talk a little bit in your book about programmed human death; we’re basically programmed to die through evolution’s weird workings and you kind of flesh out what Josh Mitteldorf calls the demographic theory…

For the June edition of Journal Club, we will be taking a look at the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies…

Researchers at the University of Virginia School of Medicine have discovered that as we age, our cells’ nuclear membranes become misshapen, which stops our genes from working properly. Nuclear membranes become distorted with age The DNA in all our cells is the same; however, the cells in our body show a great range of variation…

Today we bring you an interview with author and researcher Dr. Josh Mitteldorf who runs the aging research blog Aging Matters. Dr. Josh Mitteldorf is an evolutionary biologist and a long-time contributor to the growing field of aging science. His work in this field has focused on theories of aging. He asks the basic question:…

The Undoing Aging conference, a joint effort between the SENS Research Foundation and Michael Greve’s Forever Healthy Foundation, took place on March 15-17 in Berlin, gathering many aging researchers, advocates, investors, and other important members of the longevity community in one place. As we invited one of the best Russian journalists at educating the public…

In a new study, researchers at the Johns Hopkins Kimmel Cancer Center have shown that the epigenetic alterations associated with cancer evolve in an erratic manner during the early stages of tumor formation [1]. These tumor-associated epigenetic changes ultimately focus on a subset of genes that are also observed in aging. Cancer and senescent cells…

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