A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation…

Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that activate the protein Maf1, repress RNA transcription, and slow genomic instability, which is one of the primary hallmarks of aging. A long chain of causes…

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging. The role of DNA damage Some researchers have long suggested that damage to our DNA is a major reason why we age…

Today on LifeXtenShow, Giuliano discusses genomic instability, one of the primary hallmarks of aging – and quite possibly the grand-daddy of them all.

A team of researchers, including Dr. David Sinclair, has recently made a new study available as a preprint prior to peer review and publication in the journal Cell. DNA damage and the double-strand break Two of the primary hallmarks of aging are genomic instability, which consists of damage to our DNA, and epigenetic alterations, which…

Today, we want to spotlight a recent study showing that boosting nicotinamide adenine dinucleotide (NAD+) levels in mice prevents age-related hearing loss. What is β-Lapachone? β-Lapachone is a quinone-containing compound that was originally isolated from the lapacho tree in South America. It is worth noting that this tree has been used as a herbal medicine…

The July journal club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater extent…

Today, we have an interview with Dr. Vera Gorbunova, who talks about the current understanding of the mechanisms of longevity and genomic stability in exceptionally long-lived mammals and how this knowledge might be used to create therapies to extend healthy human lifespan. Dr. Vera Gorbunova is an endowed Professor of Biology at the University of…

Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging. DNA damage as a driver of aging Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage…

The mitochondria are the powerhouses of the cell, producing ATP, a kind of universal energy used in cellular functions. Mitochondrial dysfunction is an important part of the aging process. As cells age, the effectiveness of the respiratory chain diminishes, increasing electron leakage and reducing ATP generation [1]. As mitochondria become more dysfunctional with age, there…

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