Journal Club will be returning on August 27 with your host Dr. Oliver Medvedik and special guest Alexander Tyshkovskiy, a Ph.D. student who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic for the journal club this month will be the recent paper “Identification and Application of Gene Expression Signatures Associated…

For the June edition of Journal Club, Dr. Oliver Medvedik and guests took a look at the recent human trial of urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates that is linked to increased levels of mitophagy in aged animals. Urolithin A is a byproduct created when bacteria in the…

For the June edition of Journal Club, Dr. Oliver Medvedik and guests will be taking a look at the recent human trial of Urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates which is linked to increased levels of mitophagy in aged animals. Join us at 13:00 EDT on our Facebook channel where…

Researchers at the Salk Institute have published new data showing that a number of Alzheimer’s drug candidates based on the supplements fisetin and curcumin also appear to slow aging in mice. Targeting aging directly to prevent disease If old age is the single most significant risk factor for diseases such as Alzheimer’s, then it makes…

There is one common public reaction to my talks that bothers me quite a bit. I am worried that after each of my lectures, people will just start taking lots of anti-aging pills without regard for dosage or effectiveness, potentially hurting themselves in the process. This is because one of the most common reactions to…

History of Metformin Metformin was originally discovered in 1922, but it did not receive approval for another fifty years or more[1]. The French physician Jean Sterne initiated the first study in humans in the 1950s; it was registered as a medicine in France in 1957, but it was not approved until 1995 in the United…

Fisetin is a naturally occurring plant polyphenol from the flavonoid group, similar to quercetin. It is present in many plants, where it acts as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. It has also been found to be a senolytic compound able…

They say you can’t buy happiness, but you can buy wine, and that’s kind of the same thing. But could drinking wine also be adding years to your life? A small compound known as resveratrol might hold the key to this question. History Grapes have been hailed as a miracle cure since 1928, when Johanna…

Meat is rich in creatine, an important energy buffer in muscle cells, and the main constituent of a popular sports supplement used by athletes. However, we’re now finding out that there’s more to creatine than ‘meats’ the eye. To be clear, it is not a good idea to wolf down loads of steaks, sausages, bacon….

History Arginine was first isolated from the extract of lupin seedlings by the German chemist Ernst Schultze in 1886. Arginine in nature Arginine is found naturally in a variety of foods, including turkey, pork, chicken, pumpkin seeds, soybeans, peanuts, spirulina, chickpeas, and lentils. Potential health benefits Arginine (also known as L-Arginine) is an important amino…

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