In this informative X10 episode, Nicola and Giuliano discuss the nine hallmarks of aging, from the well-known 2013 paper of the same name. All nine of the hallmarks are addressed at once, but don’t worry; the hallmarks will be discussed individually in later episodes. ?

Today, we conclude our ongoing series discussing the Hallmarks of Aging [1] by looking at the hallmark of altered intercellular communication, the change in signals between cells that can lead to some of the diseases and disabilities of aging. As an integrative hallmark, altered intercellular communication is caused by other hallmarks of aging. As a…

Today, we will be covering another important root cause of aging, mitochondrial dysfunction, which is one of the Hallmarks of Aging [1]. What are mitochondria? Mitochondria, which are often called the powerhouses of cells, act like miniature factories, converting the food we eat into usable energy in the form of a chemical called adenosine triphosphate…

Today, as part of our series on the Hallmarks of Aging, we will be looking at the antagonistic hallmark of stem cell exhaustion. What are stem cells? As explained by an earlier article in this series, while every cell in your body has the same genetic code, regions of DNA are turned off and on…

This is part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases. Today, we will be looking at the hallmark of cellular senescence. What are senescent…

Today, as part of our series of articles that cover the Hallmarks of Aging, we are going to take a look at the role of proteins in cellular function and how they play a key role in aging. Proteins are essential for cellular function Proteins are large, complex molecules that regulate almost everything in your…

Today, as part of our ongoing series covering the hallmarks of aging, we are taking a look at nutrient sensing and how its four pathways regulate metabolism and influence aging. The four associated key protein groups are IGF-1, mTOR, sirtuins, and AMPK. We call these proteins “nutrient sensing” because nutrient levels influence their activity. IGF-1…

This is the third part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases [1]. Today, we will be looking at one of the primary hallmarks,…

This is the second part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into a number of distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases [1]. Today, we will be looking at one of…

The Hallmarks of Aging, published in 2013, is highly regarded in academia and is one of the most cited papers in biology, with an average of being cited once every two days. The paper divides aging into nine distinct categories (“hallmarks”) of damage to explain how aging processes work and how they cause age-related diseases…

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