Scientists could be one step closer to a solution to atherosclerosis by preventing the buildup of plaques that clog the arteries and lead to strokes and heart attacks. What is atherosclerosis? Atherosclerosis is the accumulation of cholesterol-containing plaques in the walls of arteries; this causes them to narrow, leading to reduced blood flow, higher blood…

New research has identified the mechanisms responsible for enhancing immune system activity, offering new approaches for more effective cancer treatments and vaccines. Invariant natural killer T (iNKT) cells are part of the immune system’s arsenal for fighting infection and defeating diseases like cancer. Finding ways to activate these potent cells more quickly could lead to…

If you need yet another reason to exercise as part of your health and longevity strategy, then check out this study, which suggests that aging of the immune system can be slowed by exercise. The problem with our modern lives is that we are, in general, much more sedentary than our ancient ancestors, who hunted…

Researchers at Harvard have described a new cancer vaccine approach that uses an injectable biomaterial scaffold to deliver a payload of tumor-specific peptides that stimulate the immune system to respond rapidly to cancer cells. Abstract Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact…

There may be other methods than drugs to destroy senescent cells, which accumulate with age. The immune system fails as we age, and rejuvenating it may be another route to removing harmful, pro-aging senescent cells. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent…

We wanted to bring your attention to an open-access publication in which the researchers suggest that the age-related decline of the thymus is more important than DNA mutation as a cancer risk factor[1]. Repairing the damage As we have discussed in this article, cancer is caused by DNA damage that creates mutations. Damage to our…

Last year, we talked about a new cancer “vaccine” currently in clinical trials in an article here, and now a second cancer vaccine is capturing media interest due to impressive results in the lab. The new therapy is now in human clinical trials for lymphoma patients. Researchers at Stanford Medicine have found that injecting two…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

Researchers at Linköping University in Sweden have discovered a new kind of warning system that plays a role in the immune system. Mitochondria in the white blood cells produce a web of DNA fibers that act as a kind of alarm. The Mitochondrial web slinger White blood cells (leukocytes) are a primary part of our…

By now, the immunotherapeutic approach to fighting cancer has become so popular that you’ve most probably already heard of it—we’ve discussed it a few times too.  While immunotherapy is currently one of the best weapons in our anticancer arsenal, it is not always effective; however, researchers at Zurich University have recently found a way to…

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