There may be other methods than drugs to destroy senescent cells, which accumulate with age. The immune system fails as we age, and rejuvenating it may be another route to removing harmful, pro-aging senescent cells. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent…

We wanted to bring your attention to an open-access publication in which the researchers suggest that the age-related decline of the thymus is more important than DNA mutation as a cancer risk factor[1]. Repairing the damage As we have discussed in this article, cancer is caused by DNA damage that creates mutations. Damage to our…

Last year, we talked about a new cancer “vaccine” currently in clinical trials in an article here, and now a second cancer vaccine is capturing media interest due to impressive results in the lab. The new therapy is now in human clinical trials for lymphoma patients. Researchers at Stanford Medicine have found that injecting two…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

Researchers at Linköping University in Sweden have discovered a new kind of warning system that plays a role in the immune system. Mitochondria in the white blood cells produce a web of DNA fibers that act as a kind of alarm. The Mitochondrial web slinger White blood cells (leukocytes) are a primary part of our…

By now, the immunotherapeutic approach to fighting cancer has become so popular that you’ve most probably already heard of it—we’ve discussed it a few times too.  While immunotherapy is currently one of the best weapons in our anticancer arsenal, it is not always effective; however, researchers at Zurich University have recently found a way to…

The search for accurate ways to measure biological age is an ongoing quest in aging research. It is important for academia to reach a consensus on robust, cost-effective, and reliable biomarkers of aging in order for the field to progress. Currently, there is a lack of reliable and fast ways to assess biological age and…

Today, we are going to take a look at a new study in which scientists at the Walter and Eliza Hall Institute of Medical Research have recently identified a type of cell that appears to be implied in thymic involution—the shrinking of the thymus[1]. Thymic involution is somewhat of a mystery in biology, a phenomenon…

Cancer can often evade the immune system by sending signals that fool it into thinking that the cancer cells are normal, healthy cells and that it should ignore them. Earlier this year, we reported on an approach to treating cancer in which the immune system can be taught to detect cancer by seeing past the…

T Cells are a major component of the formidable immune system that the body keeps at the ready to respond to the first sign of infection or disease. T cells detect if cells have been infected with a virus; upon detection, they trigger these cells’ ablation and destroy the virus. Unfortunately, the T cells do…

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