A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage. Casting a deadly NET As we age, we suffer from the ever-increasing chronic inflammation known as inflammaging. This persistent, smoldering background of low-grade inflammation harms wound healing and…

Last year, resTORbio announced the positive results of its phase 2b human trial, which targeted the aging immune system with an immune system-boosting drug. Now, the company has announced the news that its therapy is moving to a phase 3 study later this year after successful negotiation with the FDA. Targeting the mTOR pathway of…

The March Journal Club hosted by Dr. Oliver Medvedik will focus on this recent study that showed transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. These findings support the idea that cognitive decline is in part due to the aging of…

There is a strong correlation between the decline of the immune system and a decrease in future lifespan. As the immune system performs a myriad of functions with a multitude of specialized cell types, its breakdown has serious ramifications for health and longevity. As we age, our immune systems steadily decline, becoming less efficient and…

Researchers at UCLA have managed to guide pluripotent stem cells into becoming adult T cells, the cells that patrol the body to kill cancer and other diseases and that are trained in our thymi. The study, published in Cell Stem Cell, was led by senior author Gay Crooks, M.D., a professor of pathology and laboratory…

A recent study by Harvard Medical School scientists suggests that defective one-carbon metabolism and cellular respiration might contribute to age-related immunosenescence, the decline of immune function typically observed during aging [1]. Abstract T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. While cellular metabolism tightly regulates…

Today, we want to highlight a study that shows the link between atherosclerosis and the age-related shrinking of the thymus, which is arguably the most important organ of the immune system [1]. The adaptive and innate immune systems and atherosclerosis The thymus is essentially like an army base where new T cells develop and are…

Today, we are pleased to announce that the results are in from a human trial that targets the aging immune system and that an immune system-boosting drug appears to be effective. Targeting TORC1 to boost the immune system As we age, the immune system becomes increasingly poor and unable to detect and fight infections. This…

In a recent study conducted by researchers at the Novartis Institutes for Biomedical Research in Massachusetts, inhibition of mTOR complex 1 boosts the immune system of aged people, decreasing their yearly rate of infections as well as increasing their response to an influenza vaccine [1]. Study summary Inhibition of the mechanistic target of rapamycin (mTOR)…

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are…

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