Cancer can often evade the immune system by sending signals that fool it into thinking that the cancer cells are normal, healthy cells and that it should ignore them. Earlier this year, we reported on an approach to treating cancer in which the immune system can be taught to detect cancer by seeing past the…

T Cells are a major component of the formidable immune system that the body keeps at the ready to respond to the first sign of infection or disease. T cells detect if cells have been infected with a virus; upon detection, they trigger these cells’ ablation and destroy the virus. Unfortunately, the T cells do…

Natural killer (NK) cells are lymphocytes, immune cells which have a powerful arsenal of cytotoxic weaponry that they can use against tumors. Unfortunately, tumors protect themselves using a protective microenvironment that shields them from attack from NK cells. This microenvironment promotes tumor growth and survival and has an immunosuppressive effect that blunts the attempts of…

A research team at MIT has used synthetic biology to create a gene circuit that triggers the immune system to attack cancer when it first detects the signs of the disease. The circuit works by only activating the immune response when two specific cancer biomarkers are detected. The new study was published in the journal…

Cancer is predominantly a disease of aging caused by genomic instability. Finding effective ways to prevent and treat cancer is therefore of great interest to those working in the field of aging research as well as those working in oncology.  Therapies that target combinations of neoantigens, distinctive markers on the surface of cancer cells that…

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