A study from the UNC School of Medicine showed that the protein NLRP12, known for its anti-inflammatory effects, also protects mice on a high-fat diet against obesity and insulin resistance; it might have a similar effect in humans [1]. Study abstract In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to…

Today, we want to draw your attention to a new study that looks at the role of chronic age-related inflammation and the decline of nerve regeneration. Inflammaging drives age-related loss of tissue regeneration Inflammation can be beneficial and serves an important purpose: it spurs regeneration and immune responses while combating pathogens and other invaders. This…

According to a new study performed by University of Illinois researchers and published in Frontiers in Immunology, a diet rich in fiber reduces inflammation in aged mice, both in the guts and the brain. This beneficial reduction is due to high levels of butyrate, which result from the fermentation of fiber during digestion [1]. Study…

Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it. There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging“. There are a number of proposed sources of inflammaging, including…

We wanted to draw your attention to a new publication by James Kirkland and his team. Kirkland is one of the pioneers of senolytics, as he demonstrated that a combination of compounds could remove senescent cells and improve healthspan in mice back in 2015 [1]. The contribution of senescent cells to aging has been the…

Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty. Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often…

Today, we are going to take a look at the emerging theory that inflammaging, a chronic, age-related background of inflammation, is caused by alterations to the populations of intestinal microbes. What is inflammaging? Inflammaging is a term coined to describe the chronic, smoldering background of inflammation that accompanies the aging process. It is constant, low-grade…

Elena Milova is at the Interventions to extend healthspan and lifespan 2018 conference in Kazan this week. This is an important conference in the aging research field, and it includes a variety of leading experts giving talks about their research. One of these experts is Dr. Andrei Gudkov, and Elena had the opportunity to talk…

Today we will be looking at new research that may provide a new treatment option for those suffering from chronic obstructive pulmonary disease. What is Chronic obstructive pulmonary disease? Chronic obstructive pulmonary disease, or COPD, is a progressive respiratory disease characterized by shortness of breath and cough with sputum production. It generally takes a long time to…

The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources. Today, we are going to take a look at inflammaging and the various known sources that promote this age-related inflammatory…

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