We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process. Macrophage Polarization For the purposes of this article, we…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

Researchers at Linköping University in Sweden have discovered a new kind of warning system that plays a role in the immune system. Mitochondria in the white blood cells produce a web of DNA fibers that act as a kind of alarm. The Mitochondrial web slinger White blood cells (leukocytes) are a primary part of our…

The search for accurate ways to measure biological age is an ongoing quest in aging research. It is important for academia to reach a consensus on robust, cost-effective, and reliable biomarkers of aging in order for the field to progress. Currently, there is a lack of reliable and fast ways to assess biological age and…

Mesenchymal stem cells (MSCs) are one of the most thoroughly studied and understood stem cell types. They are used in a wide range of therapies, and the many studies using MSCs have enjoyed varied levels of success, depending on delivery methods, patients, co-therapies and other factors. Today, we will be taking a look at MSCs…

This episode we covered the following paper and talked about the increasingly important role the gut microbiota has in the aging process. Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., … & Schertzer, J. D. (2017). Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host…

Atherosclerosis is the number one killer in the world, and science is working on solutions to combat this age-related disease. A new mouse study has shown that the drug trodusquemine can melt away the accumulated arterial plaques that lead to heart attacks and strokes. What is Atherosclerosis? Atherosclerosis is an age-related disease in which toxic,…

The levels of circulating inflammatory cytokines and other signaling factors increase with age, contributing to the loss of tissue maintenance, wound healing difficulties, immune system dysfunction, loss of stem cell mobility and a host of other problems. However, it remains a subject of much debate as to what starts the cascade of inflammation that drives…

Many of us have experienced the uphill struggle to control our weight as we get older. We cannot eat whatever we like and stay slim like when we were younger, our holiday indulgences refusing to go away. The battle of the bulge gets harder the older we get, and there was little we could do…

The immune system is like an army keeping us safe from invasion, injury and infection and helps us to regenerate and repair tissues and organs. However, the immune system is sometimes a double-edged sword that does more harm than good. A lot of focus has been on the role of macrophages and their ability to…

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