This episode we covered the following paper and talked about the increasingly important role the gut microbiota has in the aging process. Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., … & Schertzer, J. D. (2017). Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host…

Atherosclerosis is the number one killer in the world, and science is working on solutions to combat this age-related disease. A new mouse study has shown that the drug trodusquemine can melt away the accumulated arterial plaques that lead to heart attacks and strokes. What is Atherosclerosis? Atherosclerosis is an age-related disease in which toxic,…

The levels of circulating inflammatory cytokines and other signaling factors increase with age, contributing to the loss of tissue maintenance, wound healing difficulties, immune system dysfunction, loss of stem cell mobility and a host of other problems. However, it remains a subject of much debate as to what starts the cascade of inflammation that drives…

Many of us have experienced the uphill struggle to control our weight as we get older. We cannot eat whatever we like and stay slim like when we were younger, our holiday indulgences refusing to go away. The battle of the bulge gets harder the older we get, and there was little we could do…

The immune system is like an army keeping us safe from invasion, injury and infection and helps us to regenerate and repair tissues and organs. However, the immune system is sometimes a double-edged sword that does more harm than good. A lot of focus has been on the role of macrophages and their ability to…

One of the most intriguing questions in biology discusses why some animals can regenerate their major body parts, such as hearts and limbs, and others cannot. A new study led by Dr. James Godwin from the MDI Biological Laboratory suggests that the innate immune system could be the answer. Secrets revealed in salamander study A…

An interesting new study has demonstrated a method to reprogram specific T cells. Much like researchers have been experimenting recently with macrophages and making them change into an anti-inflammatory rather than a proinflammatory type, the team here has achieved similar results with T cells. As we age, the immune system becomes dysfunctional, either due to…

The immune system plays a key role in tissue regeneration, and the various types of immune cells, such as macrophages, can help or hinder that repair process. Inflammation is part of the immune response, but with aging that immune response becomes deregulated and the inflammation becomes excessive. Excessive levels of inflammation generally speaking inhibit tissue…

The evidence that the immune system, and in particular the various types of tissue resident macrophages, play an important role in the regeneration of tissue continues to mount up. The difference in the behaviour of these macrophages varies between species and may significantly contribute to the differences in regenerative capacity observed between slow regenerative species,…

Following on from the two articles published last week about treating Parkinson’s and Atherosclerosis by adjusting macrophage populations to facilitate healing, we have yet another study[1]. This time the focus of the research is on peripheral nerve injury, but again using the same approach of the two studies we previously reported on. What is peripheral…

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