Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it. There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging“. There are a number of proposed sources of inflammaging, including…

We wanted to draw your attention to a new publication by James Kirkland and his team. Kirkland is one of the pioneers of senolytics, as he demonstrated that a combination of compounds could remove senescent cells and improve healthspan in mice back in 2015 [1]. The contribution of senescent cells to aging has been the…

Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty. Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often…

Today, we are going to take a look at the emerging theory that inflammaging, a chronic, age-related background of inflammation, is caused by alterations to the populations of intestinal microbes. What is inflammaging? Inflammaging is a term coined to describe the chronic, smoldering background of inflammation that accompanies the aging process. It is constant, low-grade…

Elena Milova is at the Interventions to extend healthspan and lifespan 2018 conference in Kazan this week. This is an important conference in the aging research field, and it includes a variety of leading experts giving talks about their research. One of these experts is Dr. Andrei Gudkov, and Elena had the opportunity to talk…

Today we will be looking at new research that may provide a new treatment option for those suffering from chronic obstructive pulmonary disease. What is Chronic obstructive pulmonary disease? Chronic obstructive pulmonary disease, or COPD, is a progressive respiratory disease characterized by shortness of breath and cough with sputum production. It generally takes a long time to…

The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources. Today, we are going to take a look at inflammaging and the various known sources that promote this age-related inflammatory…

Nicotinamide adenine dinucleotide (NAD+), a nucleotide, is critical for life to exist. From the most simple bacteria to complex multicellular organisms such as humans, NAD is a vital component of cellular function and thus life. An increased level of NAD+ appears to convey health and longevity, and a decrease is associated with aging and disease….

We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process. Macrophage Polarization For the purposes of this article, we…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

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