A new study outlines multiple ways in which epiblast stem cells can be reprogrammed back into a fully pluripotent state, paving the way for a better understanding of epigenetics. The role of epigenetics Epigenetics are why our cells, which all have the same DNA, differ in function. A bone cell has the same genetics as…

Earlier this year at the Undoing Aging conference in Berlin, I had the opportunity to listen to a debate between Dr. Vadim Gladyshev of Harvard Medical School and Aubrey de Grey of the SENS Research Foundation. The topic was “Is comprehensive damage repair feasible?” What followed was a friendly and interesting discussion about the three…

Mesenchymal stem cells (MSCs) have been a topic of great interest in the last decade or so due to their ability to improve tissue regeneration merely by their presence and the secreted signals they give out. Adult MSCs have traditionally been used for regenerative medicine with hit-and-miss results, depending on the quality and age of…

We recently attended the Undoing Aging Conference in Berlin and had the opportunity to interview Professor Vittorio Sebastiano of Turn.Bio, a company developing partial cellular reprogramming techniques to reverse cellular aging. As we age, our cells experience changes to their epigenetic markers, and this, in turn, changes gene expression, which is proposed to be a…

Researchers at UC San Francisco have taken science a step closer to creating stem cells that are effectively “invisible” to the immune system. This may ultimately lead to the production of “off-the-shelf” stem cell therapies that do not need to be patient matched. The immune system is a double-edged sword One of the big challenges…

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