Today, we want to point out a new publication that recently appeared in the Science Translational Medicine journal, as its authors have discovered a new mechanism by which the brain protects itself from the harmful α-synuclein protein aggregates associated with Parkinson’s and that may open the door to new therapies against these conditions. To understand…

In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are working on ways to boost the activity of the…

Researchers from Scripps Research have discovered how the proteasome, which is made of protein complexes in the cell that breaks down damaged and unwanted proteins, converts energy into motion to unfold target proteins for recycling. What is the proteasome? The proteasome is a protein complex whose job is to break down and recycle proteins that…

Through a new approach dubbed AMBAR, the biotechnology company Grifols has attempted to reduce the amount of harmful, Alzheimer’s disease-causing amyloid beta in the brain by collecting it with a blood protein called albumin and draining it out of the bloodstream. This approach differs from the previous antibody and catabody approaches and offers new hope…

Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share. Misfolded proteins cause multiple age-related diseases Proteins are…

Today, we would like to share with you the talk given by Kelsey Moody, CEO of Biotech Company Ichor, at the recent Ending Age-Related Diseases: Investment Prospects & Advances in Research conference in New York City. In this talk, Kelsey discusses Ichor’s protein engineering platform, how Ichor has used it, and Ichor’s plans for using it to…

Today, as part of our series of articles that cover the Hallmarks of Aging, we are going to take a look at the role of proteins in cellular function and how they play a key role in aging. Proteins are essential for cellular function Proteins are large, complex molecules that regulate almost everything in your…

Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain. The new study was published in the journal Nature in January 2018 [1]….

Suppose that your full-time job is to proofread machine-translated texts. The translation algorithm commits mistakes at a constant rate all day long; from this point of view, the quality of the translation stays the same. However, as a poor human proofreader, your ability to focus on this task will likely decline throughout the day; therefore,…

In a paper published on March 15, 2018, in the journal Science, Stanford researchers led by Dr. Dena Leeman showed that intracellular protein aggregates accumulate within the lysosomes of neural stem cells that were previously thought not to suffer from this problem [1]. Intracellular waste disposal 101 Dysfunctional proteins and organelles within a cell constitute…

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