Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain. The new study was published in the journal Nature in January 2018 [1]….

Suppose that your full-time job is to proofread machine-translated texts. The translation algorithm commits mistakes at a constant rate all day long; from this point of view, the quality of the translation stays the same. However, as a poor human proofreader, your ability to focus on this task will likely decline throughout the day; therefore,…

In a paper published on March 15, 2018, in the journal Science, Stanford researchers led by Dr. Dena Leeman showed that intracellular protein aggregates accumulate within the lysosomes of neural stem cells that were previously thought not to suffer from this problem [1]. Intracellular waste disposal 101 Dysfunctional proteins and organelles within a cell constitute…

In the January Journal Club, we discussed the new drug J147 which targets mitochondrial dysfunction to potentially treat Alzheimer’s and other age-related diseases. We have also discussed the topic in an article last week if you wish to read about the progress being made with this drug. Reference Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff,…

In a paper in the Proceedings of the National Academy of Sciences, a research team led by Carlo Condello presented their results from a study of the sliced brain fragments of deceased Alzheimer’s disease (AD) patients. It appears different amyloid-beta prions are uniquely associated with different AD variants [1]. A primer on Alzheimer’s disease AD…

Scientists at the École polytechnique fédérale de Lausanne (EPFL) have found a way to make mitochondria more resistant to damage, which could potentially be used to halt Alzheimer’s and other, similar, diseases. Globally, Alzheimer’s disease is the most common form of dementia and cause of neurodegeneration. It causes brain damage and symptoms such as long-term…

We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We chose to cover one of the most cited and highly regarded damage theories of aging in this edition of the club. In this edition of Journal Club, we…

The next Journal Club will be on October 31st at 13:00 EST/18:00 UK and will be streamed live from the Cooper Union, New York, to our Facebook page. The last episode we talked about the hallmarks of aging, a popular aging theory that places the various aging processes into of a number of damage categories (hallmarks) and proposes solutions…

We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We chose to cover one of the most cited and highly regarded damage theories of aging in this edition of the club.  In this edition of Journal Club we…

PCSK9 inhibitors, a new type of therapy, has arrived and appear to be an effective therapy for lowering LDL cholesterol to a level that exceeds the current standard of care. Recently, the results from a clinical trial at Brigham and Women’s Hospital showed that the drug evolocumab, when combined with statins, significantly and safely reduced…

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