The macrophages resident in the brain and spinal cord appear to be a key element in the progression of Alzheimer’s disease, according to the results of a new mouse study. Microglial mayhem As we age, our immune cells become increasingly dysfunctional; once-helpful cells can behave in harmful ways, promoting persistent inflammation, impairing tissue regeneration, and…

A study on animals with autoimmune myocarditis was recently released in the journal Cell Reports [1], showing the impact of heart inflammation on the types of immune cell that are formed in the heart. This could have a significant impact on our understanding of cardiac aging. What is myocarditis and how is it relevant to…

In 2018, Reason and Bill Cherman founded Repair Biotechnologies, which, as its name suggests, is a rejuvenation biotechnology company focused on damage repair approaches to aging. The company has recently completed a seed round of investment funding, with a total of $2.15 million being put into the company’s coffers to bolster research and development. Reason…

Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging. We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in…

Today, we want to highlight a study that shows the link between atherosclerosis and the age-related shrinking of the thymus, which is arguably the most important organ of the immune system [1]. The adaptive and innate immune systems and atherosclerosis The thymus is essentially like an army base where new T cells develop and are…

Researchers have manipulated the immune system to respond more aggressively to cancer according to a new study [1]. Manipulating macrophages We have discussed modulating the immune system multiple times recently, especially in regards to macrophages and manipulating their behavior. Macrophages are part of the innate immune system and carry out a wide variety of tasks,…

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are…

Elena Milova is at the Interventions to extend healthspan and lifespan 2018 conference in Kazan this week. This is an important conference in the aging research field, and it includes a variety of leading experts giving talks about their research. One of these experts is Dr. Andrei Gudkov, and Elena had the opportunity to talk…

Researchers at the University of Alabama at Birmingham have discovered a potential target for therapies that may prevent or delay heart failure from pressure overload of the heart. It could also be a biomarker to warn physicians that a patient is at risk of this happening. Early macrophage infiltration is a step in heart failure…

We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process. Macrophage Polarization For the purposes of this article, we…

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