Today, we want to highlight a study that shows the link between atherosclerosis and the age-related shrinking of the thymus, which is arguably the most important organ of the immune system [1]. The adaptive and innate immune systems and atherosclerosis The thymus is essentially like an army base where new T cells develop and are…

Researchers have manipulated the immune system to respond more aggressively to cancer according to a new study [1]. Manipulating macrophages We have discussed modulating the immune system multiple times recently, especially in regards to macrophages and manipulating their behavior. Macrophages are part of the innate immune system and carry out a wide variety of tasks,…

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are…

Elena Milova is at the Interventions to extend healthspan and lifespan 2018 conference in Kazan this week. This is an important conference in the aging research field, and it includes a variety of leading experts giving talks about their research. One of these experts is Dr. Andrei Gudkov, and Elena had the opportunity to talk…

Researchers at the University of Alabama at Birmingham have discovered a potential target for therapies that may prevent or delay heart failure from pressure overload of the heart. It could also be a biomarker to warn physicians that a patient is at risk of this happening. Early macrophage infiltration is a step in heart failure…

We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process. Macrophage Polarization For the purposes of this article, we…

Atherosclerosis is the number one killer in the world, and science is working on solutions to combat this age-related disease. A new mouse study has shown that the drug trodusquemine can melt away the accumulated arterial plaques that lead to heart attacks and strokes. What is Atherosclerosis? Atherosclerosis is an age-related disease in which toxic,…

The levels of circulating inflammatory cytokines and other signaling factors increase with age, contributing to the loss of tissue maintenance, wound healing difficulties, immune system dysfunction, loss of stem cell mobility and a host of other problems. However, it remains a subject of much debate as to what starts the cascade of inflammation that drives…

Many of us have experienced the uphill struggle to control our weight as we get older. We cannot eat whatever we like and stay slim like when we were younger, our holiday indulgences refusing to go away. The battle of the bulge gets harder the older we get, and there was little we could do…

One of the most intriguing questions in biology discusses why some animals can regenerate their major body parts, such as hearts and limbs, and others cannot. A new study led by Dr. James Godwin from the MDI Biological Laboratory suggests that the innate immune system could be the answer. Secrets revealed in salamander study A…

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