Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1…

In a paper published in Developmental Cell, scientists from Yale University have demonstrated how targeting multiple pathways related to aging with different drug combinations can slow aging down and extend healthy lifespan in C. elegans [1]. Abstract There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be…

Scientists at Lund University, Sweden showed that it is possible to prevent type 2 diabetes in mice by inhibiting a protein known as VDAC1. This inhibitor might be employed in treating this disease in humans [1]. Abstract Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We…

A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1]. Study abstract Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia…

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD