A recent study published in Cell Stem Cell shows that fasting and metformin are effective in a mouse model of demyelination, which is caused in humans by such disorders as multiple sclerosis. Myelin, demyelination, and remyelination Myelin, a substance rich in beneficial proteins and fats, is an insulator and protector of nerve cells and helps…

Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1…

In a paper published in Developmental Cell, scientists from Yale University have demonstrated how targeting multiple pathways related to aging with different drug combinations can slow aging down and extend healthy lifespan in C. elegans [1]. Abstract There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be…

Scientists at Lund University, Sweden showed that it is possible to prevent type 2 diabetes in mice by inhibiting a protein known as VDAC1. This inhibitor might be employed in treating this disease in humans [1]. Abstract Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We…

A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1]. Study abstract Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia…

History of Metformin Metformin was originally discovered in 1922, but it did not receive approval for another fifty years or more[1]. The French physician Jean Sterne initiated the first study in humans in the 1950s; it was registered as a medicine in France in 1957, but it was not approved until 1995 in the United…

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