This episode we covered the following paper and talked about the increasingly important role the gut microbiota has in the aging process. Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., … & Schertzer, J. D. (2017). Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host…

The next Journal Club will be on November 28th at 13:00 EST/18:00 UK and will be streamed live from the Cooper Union, New York, to our Facebook page. We will be discussing the following paper and be exploring the weird and wonderful world of the microbiota and its role in aging. Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A.,…

Cytomegalovirus (CMV) is a β-herpesvirus that infects the majority of people in the world, lying dormant and waiting for an opportunity to strike. This persistent virus remains in people for their entire lives once they are infected. CMV contributes to microbial burden as we age, and our dwindling immune cell populations are tied up keeping…

The topic of the gut microbiota is increasingly in the news of late, and its connection with chronic age-related inflammation, known as inflammaging, is becoming increasingly clear. What is the microbiota? The microbiota describes the community of symbiotic and pathogenic microorganisms that live in and on all multicellular organisms, and it includes bacteria, archaea, protists,…

The levels of circulating inflammatory cytokines and other signaling factors increase with age, contributing to the loss of tissue maintenance, wound healing difficulties, immune system dysfunction, loss of stem cell mobility and a host of other problems. However, it remains a subject of much debate as to what starts the cascade of inflammation that drives…

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