A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause of cognitive decline Microglia are immune cells that reside…

Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging. We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in…

Scientists at the Mayo Clinic have implicated senescent cells in yet another age-related pathology—namely, Alzheimer’s disease. Led by Dr. Darren Baker, the Mayo Clinic team discovered that clearing senescent microglia and astrocytes in murine brains leads to a much better prognosis for neurodegenerative disease [1]. Study abstract Cellular senescence, which is characterized by an irreversible…

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