Today, we will be covering another important root cause of aging, mitochondrial dysfunction, which is one of the Hallmarks of Aging [1]. What are mitochondria? Mitochondria, which are often called the powerhouses of cells, act like miniature factories, converting the food we eat into usable energy in the form of a chemical called adenosine triphosphate…

Today, we have an update from the MitoSENS team over at the SENS Research Foundation. As some of you may recall, MitoSENS was the first project we hosted on our research fundraising platform Lifespan.io back in August 2015. The project was successfully funded and raised $46,128, which was 153% of the funds needed. The extra…

In a new study, researchers have identified a direct link between mitophagy and inflammation. Aging is accompanied by rising levels of oxidative stress, which is primarily caused by our cellular power plants, the mitochondria. As we age, our mitochondria start to produce an increasing amount of oxidized molecules known as reactive oxygen species (ROS), which…

In what appears to be a world first, scientists at the University of Alabama at Birmingham have reversed two of the most common visual signs of aging—skin wrinkles and hair loss—in mice by turning off a gene responsible for mitochondrial dysfunction [1]. Study abstract Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes, mitochondrial…

According to scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, or DKFZ), the enzyme TXNIP, which inhibits the enzyme TRX-1, might be a regulator of aging and might be a viable candidate for future interventions against age-related diseases [1]. Study summary The “free radical theory of aging” suggests that reactive oxygen species (ROS) are…

Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease. Summary While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and…

Earlier this month, we covered a recent human clinical trial of the supplement MitoQ, which showed some interesting results. We thought that we would explore the publication a bit deeper, take a look at the figures, and discuss the findings in this month’s Journal Club. You can find the publication here. Abstract Excess reactive oxygen…

A human study of the mitochondrial antioxidant MitoQ shows promise in addressing some aspects of vascular aging. Antioxidant-based therapeutics to forestall the effects of aging have had a long history, ever since the elaboration of the free radical theory of aging by Denham Harmon in 1956. However, this long history has also had mixed results,…

The mitochondria are the powerhouses of the cell, producing ATP, a kind of universal energy used in cellular functions. Mitochondrial dysfunction is an important part of the aging process. As cells age, the effectiveness of the respiratory chain diminishes, increasing electron leakage and reducing ATP generation [1]. As mitochondria become more dysfunctional with age, there…

One of the proposed mechanisms driving the aging process is an increase with age of so-called reactive oxygen species (ROS), also known as free radicals. These chemical species contain unpaired electrons in the outermost orbitals of some of their atoms, which makes them extremely reactive as they attempt to snatch electrons from other atoms to…

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