The results of a clinical trial using bone marrow-derived mesenchymal stromal cells (MSCs) to treat late-stage knee osteoarthritis were published recently, and they came back positive. The trial included both phase 1 and 2 and was designed to determine the safety and efficacy of MSC stem cell therapy. A battery of tests During the trial,…

Today, we want to point out a new study suggesting that senescent cells in bone marrow cell populations contribute to the decline of the hematopoietic system, particularly the hematopoietic stem and progenitor cells (HSPCs) that live in the bone marrow and produce our blood cells [1]. The hematopoietic system and immunosenescence The hematopoietic system is…

Today, we want to highlight results from human trials in which stem cell transplants have been shown to reduce age-related frailty. Age-related frailty and stem cell transplants Currently, there are no specific approved therapies to address age-related frailty, which can cause elderly people to suffer potentially fatal falls and injuries. There has been considerable interest…

A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1]. Study abstract Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia…

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD