Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease. Summary While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and…

Researchers from the University of Texas have discovered how NAD+ creation and consumption in cells is linked to glucose metabolism and their transformation from preadipocytes into adipocytes, or as most people know them, fat cells. INTRODUCTION Nicotinamide adenine dinucleotide (NAD) is an essential small molecule that is involved in a variety of physiological and pathological processes….

Today, we have an interview with Dr. Nichola Conlon, one of the speakers at the Undoing Aging 2018 Conference in Berlin, hosted by the Forever Healthy Foundation and SENS Research Foundation. Introducing Nuchido Dr. Conlon is the CEO of Nuchido, a new company that is set to launch later this year and was encouraged in…

Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be…

A team of Harvard Medical School scientists led by Dr. David Sinclair has successfully reversed the aging of blood vessels in a new study, and human trials are currently underway. The therapy restores blood vessel growth and muscle vitality and boosts exercise endurance in aging animals. Age-related muscle wastage is linked to vascular aging The…

This is part one of a two-part article where we take a look at NAD+ biology, its history, how it relates to the biology of aging, and the potential for therapeutic interventions via the so-called NAD+ precursors. What is NAD+? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a…

Nicotinamide adenine dinucleotide (NAD+), a nucleotide, is critical for life to exist. From the most simple bacteria to complex multicellular organisms such as humans, NAD is a vital component of cellular function and thus life. An increased level of NAD+ appears to convey health and longevity, and a decrease is associated with aging and disease….

DNA is a critical part of cells, the instruction manual for building them. While DNA is well protected within the cell nucleus, damage does occur; therefore, DNA repair is absolutely essential for cell function, cell survival, and the prevention of cancer. The good news is that cells can repair damaged DNA, but the bad news…

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