A new open access paper takes a look at tryptophan and the role that it plays in the dysfunction of the immune system in the context of the age-related changes that occur in the microbiome [1]. The microbiome The gut microbiome is a complex ecosystem of bacteria, archaea, eukarya, and viruses that live inside of…

A human trial of NMN has recently concluded, and the results are not impressive at all; however, this is perfectly fine because that was not the purpose of the study, and, despite the lackluster results, the study was a success! This might sound strange, but perhaps the words of the study authors may make it…

As part of the LEAF Longevity Bookclub and to celebrate the launch of Dr. David Sinclair’s new book, Lifespan: Why We Age and Why We Don’t Have To, we hosted a special webinar on the 18th of September. The new book takes us on a journey through the biology of why we age and spotlights the…

Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the most well-known researchers in the field of rejuvenation, and his lab is the beneficiary of a successful Lifespan.io campaign. Today, Dr. Sinclair is releasing his book on Amazon, “Lifespan: Why We Age and Why We Don’t Have To”, and on…

The Forever Healthy Foundation has recently launched the Rejuvenation Now project, and it has just published a detailed analysis of NAD+ repletion therapies, providing the first scientific overview of this particular approach and of the supplements currently available. One industry, two types of people The field of aging research with an aim to rejuvenating the…

The July journal club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater extent…

Today, we want to highlight a recent human trial of the popular supplement nicotinamide riboside, a compound that has been shown in mice to restore NAD+ levels. The compound has had impressive results against some aspects of aging in mouse studies, and there is now some more data for NR in humans [1]. What is…

Exercise really does influence how we age, and a new study shows how regular exercise in later life can help offset the decline of NAD+ and NAMPT, two important molecules that facilitate cellular energy production, in skeletal muscle. NAD+ and mitochondria The mitochondria are the power stations of the cell and provide the energy that…

Researchers from Washington University School of Medicine in St. Louis have discovered a way to delay aging in mice with a protein that is abundant in the blood of young mice but declines with age. eNAMPT and the NAD salvage pathway That protein is extracellular nicotinamide phosphoribosyltransferase (eNAMPT), and it plays a key role in…

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors. What are epigenetic alterations? One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations….

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