As part of the LEAF Longevity Bookclub and to celebrate the launch of Dr. David Sinclair’s new book, Lifespan: Why We Age and Why We Don’t Have To, we hosted a special webinar on the 18th of September. The new book takes us on a journey through the biology of why we age and spotlights the…

Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the most well-known researchers in the field of rejuvenation, and his lab is the beneficiary of a successful Lifespan.io campaign. Today, Dr. Sinclair is releasing his book on Amazon, “Lifespan: Why We Age and Why We Don’t Have To”, and on…

The Forever Healthy Foundation has recently launched the Rejuvenation Now project, and it has just published a detailed analysis of NAD+ repletion therapies, providing the first scientific overview of this particular approach and of the supplements currently available. One industry, two types of people The field of aging research with an aim to rejuvenating the…

The July journal club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater extent…

Today, we want to highlight a recent human trial of the popular supplement nicotinamide riboside, a compound that has been shown in mice to restore NAD+ levels. The compound has had impressive results against some aspects of aging in mouse studies, and there is now some more data for NR in humans [1]. What is…

Exercise really does influence how we age, and a new study shows how regular exercise in later life can help offset the decline of NAD+ and NAMPT, two important molecules that facilitate cellular energy production, in skeletal muscle. NAD+ and mitochondria The mitochondria are the power stations of the cell and provide the energy that…

Researchers from Washington University School of Medicine in St. Louis have discovered a way to delay aging in mice with a protein that is abundant in the blood of young mice but declines with age. eNAMPT and the NAD salvage pathway That protein is extracellular nicotinamide phosphoribosyltransferase (eNAMPT), and it plays a key role in…

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors. What are epigenetic alterations? One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations….

Aging is a series of processes in which the body’s ability to perform functions gradually decreases. The Hallmarks of Aging includes such things as an increase in senescent cells and a decrease in stem cells, but decreasing NAD+ and increasing free radicals matter as well. This article will cover a few root causes of aging…

Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry organ Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste products for disposal and supply the brain with an…

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD