Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1…

Today, we want to highlight a recent, small-scale study looking at NAD+ and how it declines with age in the plasma. The researchers looked at various NAD+ metabolites across age groups and found that the amounts of some of them, particularly NAD+ itself, are significantly smaller in older people than younger ones [1]. This is…

A new study suggests that NAD+, which declines with age, may be increased via the de novo pathway. What is NAD? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine…

Yesterday, we announced the successful completion of the NAD+ Mouse Project after a great fundraiser, but it seems we are not done yet. The research team at Harvard has announced a new stretch goal for the last two days of the campaign. A new $75,000 goal is to be the final step, and to support…

Great news! The NAD+ Mouse Project has passed its second fundraising stretch goal, which means that the experiment will greatly expand its scope. The research team will now have enough funding to buy enough NMN to conduct long-term studies on its effects on health and the aging processes. The project will monitor the mice for…

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on Lifespan.io. There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging. Dr. David A. Sinclair…

Today, we are delighted to announce that there is to be a third funding match for the NAD+ Mouse Project! Dr. David Sinclair will be personally matching the next $5000 in donations for the last 10 days of the campaign to help reach the final $60,000 goal. Now, that is what we call a devoted…

In support of the NAD+ Mouse Project over at Lifespan.io, Dr. David Sinclair will be doing an AMA on Reddit Futurology Tuesday, October 23, 2018 from 11:00 – 12:00 AM EDT. Dr. Sinclair will be answering questions from the community about his work with NAD+ biology, Sirtuins, and why the NAD+ Mouse Project is important…

We have wonderful news today: the NAD+ Mouse Project has reached the first stretch goal of $45k! This greatly expands the scope of the experiment, which will now include a long-term study of the effects of NMN on aging in regular and ICE mice. Attaining our first stretch goal will enable us to perform longer…

Today, we have an interview with Dr. Michael Bonkowski, an expert on NAD+ biology and aging from the David Sinclair Lab, Harvard Medical School. Michael Bonkowski aims to advance our understanding of the links between metabolism, aging, and age-associated diseases. He has published 35 peer-reviewed journal articles and has conducted multiple successful longevity studies. In…

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