You know the story, and it happens to us all eventually: the older we get, the harder our brains find it to learn and remember new things. There are likely to be a myriad of reasons why the brain gets increasingly worse as we age, but these reasons are still poorly understood. Like the old…

Researchers from the Salk Institute have discovered that a protein called Chrdl1, secreted by astrocytes, is responsible for driving synapse maturation and limiting brain plasticity later in life [1]. Abstract In the developing brain, immature synapses contain calcium-permeable AMPA glutamate receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium-impermeable AMPARs as synapses stabilize and mature….

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