Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for…

We recently did an Ask Me Anything (AMA) event on our Facebook page. We get a lot of questions about our work, many of which are frequent, so we decided that this popular format would be the best way to answer them. The panel featured LEAF Board Directors Keith Comito, Dr. Oliver Medvedik, Elena Milova,…

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union in New York City. This conference was designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights. Dr. Oliver Medvedik, LEAF vice president and Director of…

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We…

This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a…

Today, we have another video from our Ending Age-Related Diseases 2018 conference. This particular video shows one of our panels, “The Current State of Aging Research”, which featured Dr. Aubrey de Grey of the SENS Research Foundation, Dr. Vadim Gladyshev of Harvard Medical School, Dr. Oliver Medvedik of Lifespan.io and the Cooper Union, and Steven…

For the August Journal Club, we took a look at a new paper that shows inhibiting TGFβ can boost liver regeneration [1]. We also discussed another related paper from 2015 by Conboy et al. which showed regeneration in aged mice was possible if TGFβ was inhibited [2]. Taken together, the two papers both confirm that systemic…

The July edition of the Journal Club has us taking a look at a recent paper that casts doubt and concern over the use of CRISPR Cas9 for gene editing. The researchers raise concerns that using it may result in genomic damage, something that was missed by previous researchers working with the powerful gene editing…

On July 12th, we hosted our first conference, Ending Age-Related Diseases: Investment Prospects & Advances in Research, at the Frederick P. Rose Auditorium, which is part of the Cooper Union campus in New York City. We are delighted to announce that the conference was a huge success with 160 attendees, a wide variety of speakers…

LEAF Vice President Dr. Oliver Medvedik and host of our monthly Journal Club recently did a podcast with Future Grind where he discusses his interest in aging research and his views on life extension. At the age of 18, he had many things he wanted to do with his life but he decided back then…

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