A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1]. Study abstract Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia…

Osteoporosis is a crippling condition provoked by an imbalance between the creation of new bone tissue and the destruction of the old, which becomes worse as we age. What causes osteoporosis to develop and progress? Osteoporosis is the failure of tissue maintenance in the bones, causing them to become weak and fragile. This increases the…

Researchers at the Mayo Clinic have revealed a causal link between senescent cells and bone loss in mice. Senescent cells are one of the hallmarks of aging, and removing them has been proposed as a way to prevent or delay age-related diseases. As your body ages, increasing amounts of your cells become senescent. Senescent cells…

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