An open-access paper published in Nature Communications sheds light on how an accumulation of α-synuclein protein in brain cells contributes to causing Parkinson’s disease. In particular, the researchers discovered how clumps of the protein damage important proteins on mitochondrial surfaces, leading to impaired energy production, swelling and bursting of the mitochondria themselves, and, ultimately, cell…

Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease. Summary While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and…

As we reported in an article yesterday, researchers are becoming increasingly interested in the potential of changing the ratio of types of macrophages present in the body to facilitate tissue regeneration and healing. This is a line of research that covers a number of topics, including aging, regeneration, tissue repair, and inflammation. Over the last…

Parkinson’s disease is one of the most well known of the neurodegenerative diseases. The symptoms include tremors and loss of motor control, which are caused by the loss of dopamine producing neurons in the brain. In fact, most of us lose these neurons as we age, but to a lesser degree. Parkinson’s sufferers have a…

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