In a world first, a patient with Parkinson’s disease has undergone transplant therapy, which uses reprogrammed stem cells to replace neurons destroyed by the disease. Stem cell therapy is part of the toolkit The stem cell field is an area of science that is relatively well funded and, out of all the branches of medical…

Researchers at Georgetown University Medical Center discovered that the protease USP13 (ubiquitin-specific peptidase 13) plays a role in the accumulation of toxic alpha-synuclein aggregates that characterize Parkinson’s disease [1]. Abstract Ubiquitin specific proteases (USPs) are de-ubiquitinases that control the protein ubiquitination cycle. The role of de-ubiquitinases is poorly understood in neurodegenerative diseases. We found that…

Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share. Misfolded proteins cause multiple age-related diseases Proteins are…

Researchers at the Department of Biological Sciences at Lehigh University in Bethlehem, Pennsylvania, discovered that a protein known as Scarlet has protective effects against the fruit fly version of Parkinson’s disease [1]. Abstract Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, resulting in progressive locomotor dysfunction. Identification of genes required for the…

Today, we would like to share with you the talk given by Kelsey Moody, CEO of Biotech Company Ichor, at the recent Ending Age-Related Diseases: Investment Prospects & Advances in Research conference in New York City. In this talk, Kelsey discusses Ichor’s protein engineering platform, how Ichor has used it, and Ichor’s plans for using it to…

An open-access paper published in Nature Communications sheds light on how an accumulation of α-synuclein protein in brain cells contributes to causing Parkinson’s disease. In particular, the researchers discovered how clumps of the protein damage important proteins on mitochondrial surfaces, leading to impaired energy production, swelling and bursting of the mitochondria themselves, and, ultimately, cell…

Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease. Summary While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and…

As we reported in an article yesterday, researchers are becoming increasingly interested in the potential of changing the ratio of types of macrophages present in the body to facilitate tissue regeneration and healing. This is a line of research that covers a number of topics, including aging, regeneration, tissue repair, and inflammation. Over the last…

Parkinson’s disease is one of the most well known of the neurodegenerative diseases. The symptoms include tremors and loss of motor control, which are caused by the loss of dopamine producing neurons in the brain. In fact, most of us lose these neurons as we age, but to a lesser degree. Parkinson’s sufferers have a…

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