We’re continuing to release talks from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology. Kevin Strange discussed his company, Novo Biosciences, and how it is developing small molecules that restore the body’s ability to…

Exercise really does influence how we age, and a new study shows how regular exercise in later life can help offset the decline of NAD+ and NAMPT, two important molecules that facilitate cellular energy production, in skeletal muscle. NAD+ and mitochondria The mitochondria are the power stations of the cell and provide the energy that…

In a small, recent human trial, a naturally occurring compound called urolithin A has yielded positive results and appears to slow down part of the aging process that is related to the production of energy in our cells. What is urolithin A? Urolithin A is the end product created when bacteria in the gut break…

In a new study, researchers have found that the zinc-finger transcription factor Slug is responsible for repressing p16Ink4a, a compound that promotes senescence in human tissue. The researchers suggest that Slug is worth exploring as a treatment for sarcopenia [1]. Satellite cells Satellite cells are specialized stem cells that form new muscle cells when the…

Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty. Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often…

Sarcopenia, a condition that causes loss of muscle mass, is a common ailment that comes with aging. It wouldn’t be correct to talk about who is affected and who isn’t, because everyone experiences at least some degree of muscle mass loss, along with reduced strength, after age 40 or 50. As you may imagine, sarcopenia’s…

Researchers at Duke University have managed to create functional human muscle tissue using skin cells as the starting point[1]. This research builds on their previous work from 2015, when they grew the first functioning muscle tissue using cells obtained from muscle biopsies[2]. Being able to create muscle cells using non-muscle tissue opens the door for…

We have all seen it, the age-related loss of muscle mass and increasing frailty that generally accompanies advancing age. Recently the World Health Organization classified this age-related muscle wastage as a disease and thus sarcopenia entered official usage to describe it. There are a number of potential causes of sarcopenia and new research suggests that…

The first results of two human clinical trials using stem cell therapy for age-related frailty have been published, and the results are very impressive indeed. The studies show that the approach used is effective in tackling multiple key age-related factors. Aging research has made significant progress in the last few years, with senescent cell clearing…

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