A small update from the MMTP project team following meeting the lead investigator Dr. Alexandra Stolzing in Berlin recently. Hi everyone, it has been a while and as we have recently spoken to Dr. Alexandra Stolzing at the Undoing Aging conference in Berlin about the MMTP we wanted to give a small update. Dr. Stolzing…

In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of…

At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without age-related diseases. Dr. Judith Campisi, one of the speakers at this conference, is a…

The presence of senescent cells has been implicated in a wide range of age-related diseases and even conditions such as T1 diabetes. Today, we want to draw your attention to a new publication that explores the relationship between senescent cells and intervertebral disc degeneration (IDD). It was already known that senescent cells increase during the…

Today, we want to point out a new study suggesting that senescent cells in bone marrow cell populations contribute to the decline of the hematopoietic system, particularly the hematopoietic stem and progenitor cells (HSPCs) that live in the bone marrow and produce our blood cells [1]. The hematopoietic system and immunosenescence The hematopoietic system is…

In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells. They demonstrate that in enlarged yeast and human cells, RNA and protein biosynthesis…

Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by without a new study showing that senolytics, drugs that remove aged and damaged cells from the body, improve organ or tissue function by reversing some…

In aging research, there has long been a need for better biomarkers that can detect and confirm the presence of senescent cells. This has become particularly urgent in recent years due to the meteoric rise of the senescent cell-clearing therapies known as senolytics. Traditional ways of measuring senescent cell populations are problematic and have multiple…

For the January Journal Club, we discussed the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin…

UNITY Biotechnologies has recently announced an expansion of its first-stage human trial of UBX0101, a drug that has been shown to have senolytic properties in mice [1] and that the company hopes will be useful in treating painful osteoarthritis of the knee. An expanded clinical trial UNITY Biotechnologies, a $495 million biotech company in the…

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