Another senolytic drug candidate has entered development at Unity Biotechnologies. The purpose of senolytics is to clear the body of harmful senescent cells, which accumulate with age and encourage age-related diseases to develop. A new treatment for age-related diseases of the eye Recently, UNITY Biotechnologies announced the selection of a new lead drug, UBX1967, with…

The results from a human pilot study that focused on treating idiopathic pulmonary fibrosis with senescent cell-clearing drugs has been published. The drugs target aged and damaged cells, which are thought to be a reason we age and get sick, and remove them from the body. Senescent cells and aging As we age, increasing numbers…

There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan. What is Fisetin? Fisetin is a naturally occurring flavonol and part of the…

The topic for the December Journal Club will be the recently published paper – Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement and a plant-based polyphenol appears to influence the aging process in mice by clearing senescent cells, one of the suggested reasons we age. There is certainly plenty of justification…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. Dr. Oliver Medvedik, Steve Hill, and Victor Bjoerk discussed this interesting study…

Today, we want to point out a new study showing how senescent cells poison their healthy neighbors and that the more there are, the faster they make other cells become senescent. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for…

At the Eurosymposium on Healthy Ageing, we had the privilege of interviewing Dr. Marco Demaria of the European Research Institute for the Biology of Ageing. In this interview with Elena Milova, Dr. Demaria primarily talks about senescent cells, their role in age-related diseases, and methods of controlling them. Among the ways of controlling them include…

We wanted to bring your attention to a recent publication that discusses the topic of cellular senescence and the contributions of senescent cells to aging and disease [1]. What is perhaps the most interesting part of this paper is the section covering the potential future directions that researchers may take in managing senescent cell populations…

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We…

© 2018 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

       Powered by MMD