There are a number of FDA-approved drugs that have shown efficacy in preclinical studies for addressing the aging process. Drugs such as rapamycin, dasatinib, and quercetin among others have all showed promise in animal studies.  Non-profit Betterhumans, known for its educational and news-related work in the transhumanist community, has announced that it will be running…

The next Journal Club will be on Tuesday, September 26th at 13:00 EST/18:00 UK and will be streamed live from the Cooper Union, New York, to our Facebook page. We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We have chosen to…

By treating one of the root causes of aging – senescent cells – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time.  Today we are going to take a look at what…

Osteoporosis is a crippling condition provoked by an imbalance between the creation of new bone tissue and the destruction of the old, which becomes worse as we age. What causes osteoporosis to develop and progress? Osteoporosis is the failure of tissue maintenance in the bones, causing them to become weak and fragile. This increases the…

Researchers at the Mayo Clinic have revealed a causal link between senescent cells and bone loss in mice. Senescent cells are one of the hallmarks of aging, and removing them has been proposed as a way to prevent or delay age-related diseases. As your body ages, increasing amounts of your cells become senescent. Senescent cells…

As your body ages, increasing amounts of your cells enter a state of cellular senescence. These cells no longer divide or support the tissues of which they are a part, and they emit a cocktail of harmful chemical signals that encourage other nearby cells to also enter the same senescent state. The presence of senescent…

Osteoarthritis is a common condition that affects your joints and is frequently associated with aging. Today, we look at a new open-access paper that discusses the role of aging in the progression of this disease. So what is osteoarthritis? Over time, the surfaces of your joints become worn and damaged, causing them to no longer…

Cellular senescence is widely considered by academia to be one of the causes of aging and one that leads to a number of age-related diseases. There has been a high level of interest in recent years in cellular senescence and approaches that seek to remove senescent cells as a route to delaying or even preventing…

Recently a journal landed on my desk involving one of my favorite subjects, aging biomarkers. The study authors have been developing a method to allow real-time visualization of senescent cells in living tissues and they have published their findings in the journal of the American chemical society here[1]. Unfortunately, like a lot of science (up…

Oisin Biotechnologies is a rejuvenation biotechnology company which received its seed funding from the Methuselah Foundation and SENS Research Foundation a few years ago. The current focus of Oisin is the targeted clearance of senescent cells, using drugs sometimes referred to as senolytics. Senescent cells are one of the hallmarks of aging, and as they…

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