Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging. DNA damage as a driver of aging Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage…

Today, we have a new study showing that a common, plant-based compound could help clear out unwanted senescent cells, which accumulate with age and produce inflammatory signals that drive age-related disease progression. Taking out the trash A new study has investigated a natural, plant-based compound for its ability to destroy senescent cells [1]. These cells…

Today, we have a guest article from Dr. Marion Tible, a scientist, and author over at the aging research-focused blog Long Long Life. What follows is an introduction to the senescent cell-clearing therapies known as senolytics, these therapies are poised to enter human trials and if successful could revolutionize how we treat age-related diseases. What…

Some time ago, we discussed the matter of beauty in the context of life extension; in particular, we tried to dispel the belief that the motivation behind life extension might be simply vanity. The article argued that there is nothing wrong with wanting to preserve youthful looks and attempted to explain the evolutionary reasons for…

The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources. Today, we are going to take a look at inflammaging and the various known sources that promote this age-related inflammatory…

Today, we wanted to bring your attention to a new open access paper. The authors here review the role of cellular senescence in the context of the cardiovascular and metabolic diseases of aging. This paper puts special focus on the aging of the vascular system and the role that accumulating numbers of senescent cells play…

Some cancer cells express some of the same genes that senescent cells do, so it makes sense that drugs that destroy senescent cells may also destroy cancer cells. This was what the researchers in this new study set out to test. Abstract p16Ink4a is a potent cell cycle inhibitor engaged to support cell cycle arrest…

In a new study, researchers at the Johns Hopkins Kimmel Cancer Center have shown that the epigenetic alterations associated with cancer evolve in an erratic manner during the early stages of tumor formation [1]. These tumor-associated epigenetic changes ultimately focus on a subset of genes that are also observed in aging. Cancer and senescent cells…

There may be other methods than drugs to destroy senescent cells, which accumulate with age. The immune system fails as we age, and rejuvenating it may be another route to removing harmful, pro-aging senescent cells. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

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