We have interviewed Dr. Peter de Keizer, a researcher who is engaged in studying senescent cells and designing therapies to destroy them in order to delay and prevent age-related diseases. Cleara Biotech is currently using his research to develop a senolytic peptide that accomplishes this via interfering with the interactions between p53 and FOXO4. Senescent…

We wanted to draw your attention to a new publication by James Kirkland and his team. Kirkland is one of the pioneers of senolytics, as he demonstrated that a combination of compounds could remove senescent cells and improve healthspan in mice back in 2015 [1]. The contribution of senescent cells to aging has been the…

Interest in therapies that remove senescent cells from the body, known as senolytics, has grown massively in the last year or so. There are now a number of companies actively developing senolytic therapies, including UNITY Biotechnology, Oisin Therapeutics, and Antoxerene. Recently, another company, Cleara Biotech, has arrived on the scene. We anticipated this last year…

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are…

Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty. Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often…

Today, we are going to take a look at the emerging theory that inflammaging, a chronic, age-related background of inflammation, is caused by alterations to the populations of intestinal microbes. What is inflammaging? Inflammaging is a term coined to describe the chronic, smoldering background of inflammation that accompanies the aging process. It is constant, low-grade…

Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging. DNA damage as a driver of aging Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage…

Today, we have a new study showing that a common, plant-based compound could help clear out unwanted senescent cells, which accumulate with age and produce inflammatory signals that drive age-related disease progression. Taking out the trash A new study has investigated a natural, plant-based compound for its ability to destroy senescent cells [1]. These cells…

Today, we have a guest article from Dr. Marion Tible, a scientist, and author over at the aging research-focused blog Long Long Life. What follows is an introduction to the senescent cell-clearing therapies known as senolytics, these therapies are poised to enter human trials and if successful could revolutionize how we treat age-related diseases. What…

Some time ago, we discussed the matter of beauty in the context of life extension; in particular, we tried to dispel the belief that the motivation behind life extension might be simply vanity. The article argued that there is nothing wrong with wanting to preserve youthful looks and attempted to explain the evolutionary reasons for…

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