In a new study, researchers at the Johns Hopkins Kimmel Cancer Center have shown that the epigenetic alterations associated with cancer evolve in an erratic manner during the early stages of tumor formation[1]. These tumor-associated epigenetic changes ultimately focus on a subset of genes that are also observed in aging. Cancer and senescent cells are…

There may be other methods than drugs to destroy senescent cells, which accumulate with age. The immune system fails as we age, and rejuvenating it may be another route to removing harmful, pro-aging senescent cells. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T…

This is the third part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases[1]. Today, we will be looking at one of the primary hallmarks, telomere…

Today, we take a look at three key emerging technologies that might add extra healthy years to your life by addressing the aging processes directly to prevent or delay age-related diseases. Senolytics – Removing aged dysfunctional cells to promote tissue regeneration As we age, increasing amounts of our cells enter into a state known as…

Today, we are going to have a look at a new study that shows that senescent, non-dividing aged cells can be somewhat restored to working order using a new technique. Before we do that, let’s take a look at what senescent cells are and how cellular senescence protects us from cancer and other harmful diseases….

The link between inflammation, cellular senescence, aging, and cancer is a complex relationship, but a new study sheds light on how these four interact. The light and dark side of inflammation and cellular senescence Cellular senescence is a protective mechanism that helps us to stay healthy and avoid cancer by removing damaged and aged cells…

We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We chose to cover one of the most cited and highly regarded damage theories of aging in this edition of the club.  In this edition of Journal Club we…

There are a number of FDA-approved drugs that have shown efficacy in preclinical studies for addressing the aging process. Drugs such as rapamycin, dasatinib, and quercetin among others have all showed promise in animal studies.  Non-profit Betterhumans, known for its educational and news-related work in the transhumanist community, has announced that it will be running…

The next Journal Club will be on Tuesday, September 26th at 13:00 EST/18:00 UK and will be streamed live from the Cooper Union, New York, to our Facebook page. We have been talking about a number of new studies in past Journal Clubs, so we thought it was time to get into some aging theory. We have chosen to…

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