The link between inflammation, cellular senescence, aging, and cancer is a complex relationship, but a new study sheds light on how these four interact. The light and dark side of inflammation and cellular senescence Cellular senescence is a protective mechanism that helps us to stay healthy and avoid cancer by removing damaged and aged cells…

So far, the only intervention that is known to consistently increase lifespan across multiple species is caloric restriction (CR). Caloric restriction is known to increase lifespan in the majority of mouse strains tested[1] and many other species. The effects of CR have even been shown to influence how primates age and reduce the incidence of…

There are a number of FDA-approved drugs that have shown efficacy in preclinical studies for addressing the aging process. Drugs such as rapamycin, dasatinib, and quercetin among others have all showed promise in animal studies.  Non-profit Betterhumans, known for its educational and news-related work in the transhumanist community, has announced that it will be running…

By treating one of the root causes of aging – senescent cells – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time.  Today we are going to take a look at what…

Researchers at the Mayo Clinic have revealed a causal link between senescent cells and bone loss in mice. Senescent cells are one of the hallmarks of aging, and removing them has been proposed as a way to prevent or delay age-related diseases. As your body ages, increasing amounts of your cells become senescent. Senescent cells…

As your body ages, increasing amounts of your cells enter a state of cellular senescence. These cells no longer divide or support the tissues of which they are a part, and they emit a cocktail of harmful chemical signals that encourage other nearby cells to also enter the same senescent state. The presence of senescent…

Cellular senescence is widely considered by academia to be one of the causes of aging and one that leads to a number of age-related diseases. There has been a high level of interest in recent years in cellular senescence and approaches that seek to remove senescent cells as a route to delaying or even preventing…

Oisin Biotechnologies is a rejuvenation biotechnology company which received its seed funding from the Methuselah Foundation and SENS Research Foundation a few years ago. The current focus of Oisin is the targeted clearance of senescent cells, using drugs sometimes referred to as senolytics. Senescent cells are one of the hallmarks of aging, and as they…

The new research work on senolyic drugs by Baar et al. uses a rationally designed molecule that selectively targets senescent cells in vivo, both in an accelerated aging mouse model, and in normally aged mice as well, with few if any side effects[1]. Senolytics are a new class of potential anti-aging drugs that function by specifically…

The breaking news today is that yet another research group has entered the field of senescent cell clearance to treat aging. Therapies that remove senescent cells are known as senolytics and they have been a hot topic for the past year or so. Before we talk about the new study, let’s take a look at…

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