Is the focus on senolytics, drugs that eliminate senescent cells, potentially damaging for longevity? In this interview, Dr. Michael Fossel, who has focused his research on telomeres and the development of telomerase therapy for decades, discusses the potential downsides of senolytics and the promise of telomerase therapy for treating age-related diseases. Senescent cells no longer…

Researchers have demonstrated that nanoparticles coated with quercetin molecules can selectively target and eliminate harmful senescent cells. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range…

A small-scale human trial by Mayo Clinic researchers has shown for the first time that harmful senescent cells that accumulate with age can be removed from the body by senolytic drugs. This has been demonstrated many times already in mice, but this is the first confirmation that these drugs remove senescent cells in the same…

The topic for the September Edition of the Journal Club was the recent human trial of senolytic agents Dastatinib and Quercetin. For the researchers at the Mayo Clinic this was a follow on study from their previous human trial targeting IPF. This time the researchers ran a study to see how senolytics influenced diabetic kidney…

For the September Journal Club, we are taking a look at the new human trial data from the recent senolytics trial at Mayo Clinic, a follow-on study from its previous human trial targeting IPF. This time, the researchers ran a study to see how senolytics influenced diabetic kidney disease and if it actually removes senescent…

The Forever Healthy Foundation has recently launched the Rejuvenation Now project, and it has just published a detailed analysis of fisetin, a naturally occurring compound present in strawberries and other fruit and sold as a dietary supplement. There is a lot of hype, pseudoscience, and outright lies attached to the supplement industry and how it…

Recently, Unity Biotechnology completed a phase 1 trial of its drug UBX0101. While the trial found that the drug was non-toxic and lacked serious side effects, many of its results were not statistically significant. UBX0101 UBX0101 aims to treat osteoarthritis and possibly other diseases of aging through directly targeting one of the aspects of aging…

Not so long ago, it was my 44th birthday, and I’ve finally decided to write something that I’ve been reflecting on for a while. To some people, a birthday is a cause for celebration; for others, it is viewed as a bad thing. Yes, if you take the negative view, you could see it as…

In a recent study, researchers have explored senescence-related proteins and protein interactions in cataracts, a leading cause of visual impairment and blindness in older adults. Cataracts are characterized by the clouding of the lens in the eye, which leads to impaired vision. Cataracts generally develop slowly and can affect either one or both eyes at…

A small update from the MMTP project team following meeting the lead investigator Dr. Alexandra Stolzing in Berlin recently. Hi everyone, it has been a while and as we have recently spoken to Dr. Alexandra Stolzing at the Undoing Aging conference in Berlin about the MMTP we wanted to give a small update. Dr. Stolzing…

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