During the Fourth Eurosymposium on Healthy Ageing (EHA), which was held in Brussels, Belgium last November, we had the opportunity to meet Dr. Daniel Muñoz-Espín from the Oncology Department of the University of Cambridge. Dr. Muñoz-Espín received his PhD from the Autonomous University of Madrid, Spain, within the viral DNA replication group at the Centre…

The topic for the December Journal Club was the recently published paper Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement, a plant-based polyphenol, appears to influence aging in mice by clearing senescent cells, which are one of the hallmarks of aging. There is certainly plenty of justification for moving this compound…

The topic for the December Journal Club will be the recently published paper – Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement and a plant-based polyphenol appears to influence the aging process in mice by clearing senescent cells, one of the suggested reasons we age. There is certainly plenty of justification…

A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive. What is aging? Aging is basically the accumulation of damage and errors caused by a collection of varied processes that harm the functions of the body…

Tau protein aggregation is associated with cellular senescence in the brain is the topic for the November Journal Club. This is an important paper as it shows how senescent cells contribute to Alzheimer’s disease and how removing them appears to improve the condition. We will see you live on our Facebook page at 13:00 EST for…

We wanted to bring your attention to a recent publication that discusses the topic of cellular senescence and the contributions of senescent cells to aging and disease [1]. What is perhaps the most interesting part of this paper is the section covering the potential future directions that researchers may take in managing senescent cell populations…

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan. SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We…

Senolytics are the first therapies that directly target an aging process in order to delay or prevent age-related diseases, and they are now in human trials. Today, we think that it is the ideal time to have a look at how they work and what companies are involved. Senescent cells and aging As we get…

Today, we want to bring your attention to a recent mouse study on fisetin, a commonly available supplement that has proven effective at destroying senescent cells. What are senescent cells? As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known…

Today, we have an update from the MMTP Project team. The project was launched on Lifespan.io back in 2016 with the aim of testing senolytics and their effect on lifespan, it was successfully funded and raised 15% over its initial goal. Hi everyone, it has been a long time so we thought it was time…

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