A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural development, they create differentiated stem cells and ultimately somatic…

A recent review shows the current state of the industry with regards to using human pluripotent stem cells (hPSCs) to create cells that are useful for the study of, and therapies for, the human heart. Pluripotent Stem Cells Stem cells are the cells that form every other cell in the body, and adult humans naturally…

Researchers at the University of Helsinki have shown why the regenerative capacity of the cells lining the intestines declines with age and that targeting a particular enzyme can restore the regenerative potential of this tissue. Notum blocks the Wnt pathway During normal function, the cells of the intestinal epithelium, a single cell layer that forms…

As published in a recent study, researchers have discovered that neural stem cells are impeded by the invasion of T cells, immune cells that are not normally present in the neural stem cell niche [1]. The neural stem cell niches Our brains contain neural stem cells (NSCs); like their name suggests, these cells are responsible…

In a new study, researchers have found that the zinc-finger transcription factor Slug is responsible for repressing p16Ink4a, a compound that promotes senescence in human tissue. The researchers suggest that Slug is worth exploring as a treatment for sarcopenia [1]. Satellite cells Satellite cells are specialized stem cells that form new muscle cells when the…

Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has been previously achieved, this experiment was more refined than older studies and sheds new light on the potential of tissue regeneration through stem cells. The…

Mesenchymal stem cells (MSCs) have been a topic of great interest in the last decade or so due to their ability to improve tissue regeneration merely by their presence and the secreted signals they give out. Adult MSCs have traditionally been used for regenerative medicine with hit-and-miss results, depending on the quality and age of…

The results of a clinical trial using bone marrow-derived mesenchymal stromal cells (MSCs) to treat late-stage knee osteoarthritis were published recently, and they came back positive. The trial included both phase 1 and 2 and was designed to determine the safety and efficacy of MSC stem cell therapy. A battery of tests During the trial,…

The March Journal Club hosted by Dr. Oliver Medvedik focused on a recent study that showed transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. These findings support the idea that cognitive decline is in part due to the aging of blood cells,…

The March Journal Club hosted by Dr. Oliver Medvedik will focus on this recent study that showed transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. These findings support the idea that cognitive decline is in part due to the aging of…

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