Researchers have demonstrated that telomerase gene therapy does not increase the risk of cancer, even in strains of mice that are particularly susceptible to cancer [1]. A tale of telomeres Short telomeres trigger cellular senescence and are thought to be one of the primary hallmarks of aging, which has led to various researchers seeking ways…

Today, we conclude our two-part interview with Dr. Michael Fossel, you can find part one here. Changing tack a bit here, you talk a little bit in your book about programmed human death; we’re basically programmed to die through evolution’s weird workings and you kind of flesh out what Josh Mitteldorf calls the demographic theory…

Today, we have part one of a two-part interview with Dr. Michael Fossel, the driving force behind Telocyte, a new company focused on telomerase therapy for various diseases, and a strong advocate of telomerase therapy to treat human disease over the past three decades. You can find part two of the interview here. I interviewed…

In the March 2018 Journal Club, we talked about how researchers found out how to supercharge stem cells in a recent article. The video is now available for you to enjoy. Reference [1] Chen, Y., J.D. Podlevsky, D. Logeswaran and J.J.-L. Chen (2018). A single nucleotide incorporation step limits human telomerase repeat addition activity. EMBO. J….

The next edition of Journal Club will be on 20th March at 13:00 EST/18:00 UK where we will be discussing a new discovery about telomerase, and a potential way we might use it to improve tissue regeneration in humans. We have talked about how the researchers found out how to supercharge stem cells in a…

In the February edition of Journal Club, we talked about the new publication by Dr. Maria Blasco which demonstrates the reversal of pulmonary fibrosis in a new mouse model. This is an important step forward for the potential treatment of fibrosis as currently there are no effective cures for this disease. We also wrote an…

Researchers at the School of Molecular Sciences at Arizona State University have discovered a potential way to supercharge our stem cells and reverse some aspects of cellular aging. The Hayflick limit Normal cells cannot divide indefinitely; they have a built-in replicative limit, which is often called the Hayflick limit after its discoverer, Leonard Hayflick. This…

The next edition of Journal Club will be on March 1st, 2018 at 13:00 EST/18:00 UK live on our Facebook page. And yes, we know it’s the February edition of the club and it’s airing in March, but we could not broadcast sooner due to things happening at Cooper Union beyond our control; we will…

Idiopathic pulmonary fibrosis is a disease associated with critically short telomeres, and it currently lacks a reliable and effective treatment. Researchers at the Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) have cured the disease in mice using telomerase therapy to lengthen short telomeres. A proof of concept for an effective…

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