A group of Spanish researchers, including Dr. Maria Blasco and others at the CNIO, have published a new study that examines the consequences of short telomeres and telomerase deficiency on the brain [1]. This study addresses an aspect of telomere attrition, one of the primary hallmarks of aging. Telomeres are repeating sequences of DNA (TTAGGG)…

The researchers of a new publication take a look at the effects of obesity on aging and consider its impact in the context of the Hallmarks of Aging, a popular theory that breaks down aging into nine distinct processes. The case for obesity accelerating aging Being overweight and carrying excessive amounts of visceral fat, a…

Aging is a series of processes in which the body’s ability to perform functions gradually decreases. The Hallmarks of Aging includes such things as an increase in senescent cells and a decrease in stem cells, but decreasing NAD+ and increasing free radicals matter as well. This article will cover a few root causes of aging…

Researchers have demonstrated that telomerase gene therapy does not increase the risk of cancer, even in strains of mice that are particularly susceptible to cancer [1]. A tale of telomeres Short telomeres trigger cellular senescence and are thought to be one of the primary hallmarks of aging, which has led to various researchers seeking ways…

Australian researchers have made a discovery about telomeres that may have implications for aging, heart disease, cancer, and other age-related diseases. So, what are telomeres?  Each of the chromosomes that store our genetic information has a telomere at each end. This protective cap consists of a specific DNA sequence that is repeated thousands of times…

Today, we conclude our two-part interview with Dr. Michael Fossel, you can find part one here. Changing tack a bit here, you talk a little bit in your book about programmed human death; we’re basically programmed to die through evolution’s weird workings and you kind of flesh out what Josh Mitteldorf calls the demographic theory…

Today, we have part one of a two-part interview with Dr. Michael Fossel, the driving force behind Telocyte, a new company focused on telomerase therapy for various diseases, and a strong advocate of telomerase therapy to treat human disease over the past three decades. You can find part two of the interview here. I interviewed…

In the March 2018 Journal Club, we talked about how researchers found out how to supercharge stem cells in a recent article. The video is now available for you to enjoy. Reference [1] Chen, Y., J.D. Podlevsky, D. Logeswaran and J.J.-L. Chen (2018). A single nucleotide incorporation step limits human telomerase repeat addition activity. EMBO. J….

In the February edition of Journal Club, we talked about the new publication by Dr. Maria Blasco which demonstrates the reversal of pulmonary fibrosis in a new mouse model. This is an important step forward for the potential treatment of fibrosis as currently there are no effective cures for this disease. We also wrote an…

Researchers at the School of Molecular Sciences at Arizona State University have discovered a potential way to supercharge our stem cells and reverse some aspects of cellular aging. The Hayflick limit Normal cells cannot divide indefinitely; they have a built-in replicative limit, which is often called the Hayflick limit after its discoverer, Leonard Hayflick. This…

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